Regular aerobic exercise improves symptoms associated with a variety of central nervous system disorders and may be used as an adjunct therapy for these disorders. There is clear evidence of exercise treatment efficacy for major depressive disorder and attention deficit hyperactivity disorder.[43][48][52][53][54][55] The American Academy of Neurology's clinical practice guideline for mild cognitive impairment indicates that clinicians should recommend regular exercise (two times per week) to individuals who have been diagnosed with this condition.[56] Reviews of clinical evidence also support the use of exercise as an adjunct therapy for certain neurodegenerative disorders, particularly Alzheimer’s disease and Parkinson's disease.[57][58][59][60][61][62] Regular exercise is also associated with a lower risk of developing neurodegenerative disorders.[60][63] A large body of preclinical evidence and emerging clinical evidence supports the use of exercise therapy for treating and preventing the development of drug addictions.[64][65][66][67][68] Regular exercise has also been proposed as an adjunct therapy for brain cancers.[69]

Thus, little is known about the effects of monitored vigorous exercise in elderly people. While significant benefits for basic motor tasks (such as balance and gait) can be achieved through different kinds of physical activity (i.e., stretching exercises, treadmill, Pilates, and strength and balance training), no conclusive relationship has been proven between its intensity and such improvements. Recently, Pau et al. [14] reported that spatiotemporal gait parameters and sit-to-stand performance significantly improve through vigorous (but not light) exercises, thus suggesting that higher levels of intensity might be more suitable in generally improving static and dynamic daily motor tasks.