Regular aerobic exercise improves symptoms associated with a variety of central nervous system disorders and may be used as an adjunct therapy for these disorders. There is clear evidence of exercise treatment efficacy for major depressive disorder and attention deficit hyperactivity disorder. The American Academy of Neurology's clinical practice guideline for mild cognitive impairment indicates that clinicians should recommend regular exercise (two times per week) to individuals who have been diagnosed with this condition. Reviews of clinical evidence also support the use of exercise as an adjunct therapy for certain neurodegenerative disorders, particularly Alzheimer’s disease and Parkinson's disease. Regular exercise is also associated with a lower risk of developing neurodegenerative disorders. A large body of preclinical evidence and emerging clinical evidence supports the use of exercise therapy for treating and preventing the development of drug addictions. Regular exercise has also been proposed as an adjunct therapy for brain cancers.
Diagram of the molecular signaling cascades that are involved in myofibrillar muscle protein synthesis and mitochondrial biogenesis in response to physical exercise and specific amino acids or their derivatives (primarily l-leucine and HMB). Many amino acids derived from food protein promote the activation of mTORC1 and increase protein synthesis by signaling through Rag GTPases.
Raphael AJ. Natural childbirth in twentieth century England; PhD thesis. London: Queen Mary University of London; 2010. In the sub-continent, Vaughan was amazed that mostly affluent women suffered physically and mentally from childbirth, while poor women typically gave birth with relative ease. She explained that the active indigenous Indian lifestyle and regular exercises that maintain a functional pelvic anatomy were abandoned by the affluent.27 Vaughan K. The shape of the pelvic brim as the determining factor in childbirth. BMJ. 1931;2(3698):939–41.10.1136/bmj.2.3698.939[Crossref], [PubMed] [Google Scholar] Vaughan also observed that traditional Indian women, who covered their entire body with garments, were at risk of medical dangers including osteopenia due to sunlight deprivation.28 Vaughan KO. The purdah system and its effect on motherhood. Cambridge: W. Heffer & Sons Limited; 1928. [Google Scholar]
Two incremental graded exercise tests until exhaustion were performed, with 4 h of rest in between. One hour before each test, the athletes received a standardised meal (2315 kJ, 73% carbohydrate, 19% protein, 8% fat). Athletes arrived in the laboratory at 07:00 after an overnight fast. The first blood sample was collected as they arrived. Immediately after the first exercise test, the second blood sample was drawn. The third and fourth blood samples were drawn before and immediately after the second test. A schematic overview of the protocol can be found in fig 1. Because it is known that venepuncture increases blood prolactin, going back to baseline within 30 min, blood was drawn before and after each test (four punctures) creating the same “stress” in each situation. The study protocol was approved by the university ethical committee.
When performed at high intensity until exhaustion, OLDE has been shown to induce both peripheral and central fatigue [11, 17, 18]. However, as the exercise performed in these studies did not take place on the same ergometer where neuromuscular function was tested, the extent of peripheral and central fatigue remained unclear. To avoid the need to transfer the participant from the exercising ergometer to the dynamometer (to assess muscle fatigue), we recently developed in our laboratory a OLDE protocol on a dynamometer, reducing the time delay between cessation of the exercise and start of neuromuscular testing . In this study, we demonstrated that both peripheral and central fatigue significantly recovered between exhaustion and after three minutes, but also that high intensity OLDE alters cortical and spinal excitability. Previous studies [8, 11, 17, 18] describing muscle fatigue induced by high intensity OLDE focused only on isometric muscle fatigue (i.e. muscle fatigue measured during isometric contractions) and did not describe the extent of isokinetic muscle fatigue (i.e. muscle fatigue measured during isokinetic contractions) and its recovery. Consequently, an additional aim of this study was to describe the isokinetic muscle fatigue and its recovery induced by high intensity OLDE.
Yoga also offers many mental benefits, such as a reduction in stress level. Greater relaxation and reduced stress leads to a host of other positive body changes including an improvement in circulation, sleep and self-confidence. A positive mental outlook also helps to maintain a healthy immune system, which in turn can ward off other serious ailments such as high cholesterol, heart disease and stroke.