Selection bias may limit generalizability to other populations of older adults since the included participants in the Generation 100 study were healthier, more educated and more physically active than nonparticipants [19]. However, our study population was diverse and included both healthy as well as older adults with comorbidities, and both inactive and very active older adults were included. The findings in the present study are based on a very large data material, and represent the most comprehensive data material on exercise patterns among older adults to date.

I believe we are coming around to the conclusion that what was recommended for years by the medical community (30 minutes of "aerobic exercise" 3-5 times a week, getting the heart rate up to 80% max. for age, etc.) has been inadequate, and of too low an intensity level. When an activity is of sufficient intensity, and not of a certain duration or repeated a certain number of times, the body will initiate a total-body response (metabolic, HDL, glucose tolerance, blood pressure, bone mineral density, immune competency, etc.) It appears that if this level of intensity is never reached, regardless of the amount of time spent or the frequency it is repeated, the beneficial response by the body never occurs, or is at least blunted.
If you ask most busy people why they don’t exercise, by far the most common reason is that that they “don’t have time.” The effort of putting on workout clothes, going to the gym and showering is simply too onerous to fit in. Even the idea of a boring home workout or a 30-minute exercise tape can feel like too much of a commitment when we’re late for work or for a date.
Choose clothes that suit your activity. In general, wear clothes that won’t restrict your movement or blood flow. For some forms of exercise, like biking, you might want to wear form-fitting clothes, but they still shouldn’t be too tight. Looser workout clothes are better for strength training, brisk walking, and sports such as basketball or soccer.[35]
My fitness goal is strength and powerlifting, so I focus on strength training, specifically on four main lifts: Overhead Press, Deadlift, Bench Press and Squat. I have a laundry list of accessory exercises I do that support muscle development in critical areas for the main lifts and strength in general. It’s been working pretty well, but I recently got to a point where I wanted to do more exercise that required movement and fast-paced work. Now I do three days of strength and two days of conditioning. My conditioning days are similar to the circuit training workouts mentioned above and one day, in particular, includes more aerobic conditioning to improve that area specifically. There’s no point in being strong if you can’t also move well!

Strength training means using resistance to work your muscles; that can be your bodyweight, dumbbells, kettlebells, sand bags, resistance bands, etc. The goal of this type of workout is to increase muscle mass. Getting stronger helps improve everyday performance (from sports to regular life), prevent injuries, and increase your metabolism. Need a primer on where to start? We’ve got you covered.

Dietary nitrate supplementation increases circulating nitrite concentration, and the subsequent reduction of nitrite to nitric oxide is promoted in hypoxic environments. Given that PO2 is lower in Type II compared with Type I muscle, this article examines the hypothesis that the ergogenicity of nitrate supplementation is linked to specific effects on vascular, metabolic, and contractile function in Type II muscle.
Studies show that with fibromyalgia, the initial rise in oxidative stress will begin to decrease as you continue your workout; however, with CFS, prolonged exercise can increase the oxidative stress and the associated pain. This is where you might feel malaise after exercise as well. You can see why it is necessary to start slow and work up with consistency. Having severe M.E. myself, I know it can be done and it does take persistence. 
For Ready-Made or Make Your Own Workouts: Fitness Builder (iPhone or iPad)- This is one of my favorite exercise apps, offering a variety of ways to exercise. You can choose workouts based on the equipment you have, the muscle groups you want to work or the type of workout you're looking for. There are a range of ready-made workouts and you can also create your own workouts from the amazing database of exercises included.

Ken Hutchins' analysis is not just book theory; it is based on real experience training many, many thousands of subjects over a span of decades. He trained everyone from amateur and professional level athletes and bodybuilders to little old ladies with osteoporosis and also a great many genetically normal/average folks. He assisted Arthur Jones and Ellington Darden at Nautilus Sports Medical Industries where he first refined the Superslow method during a 5 years long clinical trial, the Nautilus Osteoporosis Study at The University of Florida Medical School in Gainesville (the study is mentioned in chapter 8 of the 1990 edition of "The Nautilus Book" by Ellington Darden, a book I highly recommend for beginning HIT practitioners). Hutchins' writing is as dry and clinical as one would expect to find in any textbook about medicine or engineering. It is also filled with rich insight into the intellectual processes and long history of carefully controlled experiments at Nautilus (and later Hutchins' own facilities) that brought Ken Hutchins to his current level of knowledge. His understanding of anatomy, biology, physics, engineering, psychology, history and sociology are all put to good use in this book and should enthrall any reader that possesses solid critical-thinking skills. Understanding the arguments for a distinction of "Exercise vs. Recreation", "The First Definition of Exercise" and "Requirements for Functional Ability" are crucial for everyone that cares even the slightest about the subject of human health, fitness, longevity or quality of life. These are not trivial matters.

Yoga, which when translated from Sanskrit means “to control” or “to unite,” is said to have originated in India thousands of years ago. While its origins are based upon religion, many yoga classes today focus more on the connection between mind, body and spirit and achieving a balance within the body. Yoga concentrates heavily on body awareness, breathing and stretching.

Exercise doesn't have to be done at the gym. You can work out in the comfort of your own home. And with calesthenic-type exercises such as squats, lunges, pushups, and sit-ups, you can use the resistance of your own weight to condition your body. To boost your strength and aerobic capacity, you may also want to invest in some home exercise equipment.
My favorites are all free, though you can subscribe for more features to most of them as well. But free works just fine. They’re all available on iOS and Android (except for one). They’re all built around the science-based concept of high-intensity circuit training using body weight, so you don’t need any fancy equipment. I’ve done these in hotel rooms, my office, parks, and even in a quiet corner at the airport waiting to get on a plane.

Multiple new, yet generally typical MMB methods originated after 1950, including the Feldenkrais Method;51 Reese M [Internet]. A biography of Moshe Feldenkrais. 2015 Aug 30 [cited 2015 Aug 30]. Available from: [Google Scholar] the modern form of Calisthenics;52 Ozer Kaya D, Duzgun I, Baltaci G, Karacan S, Colakoglu F. Effects of calisthenics and Pilates exercises on coordination and proprioception in adult women: a randomized controlled trial. J Sport Rehabil. 2012;21(3):235–43. [Google Scholar] Gyrokinesis and Gyrotonic by Horvath;53 Gyrotonic and Gyrokinesis [Internet]. 2015 Aug 30 [cited 2015 Aug 30]. Available from: [Google Scholar] Gaga by Naharin54 Gaga [Internet]. 2015 Aug 28 [cited 2015 Aug 30]. Available from: [Google Scholar] and CoreAlign55 The CoreAlign [Internet]. 2015 Aug 30 [cited 2015 Aug 30]. Available from: [Google Scholar] and Human Harmony by Hoffman.56 Human Harmony Training [Internet]. 2015 Aug 30 [cited 2015 Aug 30]. Available from:!human-harmony-training/c66t. [Google Scholar] In recent decades, many allied health professionals and therapists have embraced the MMB concepts as an integral part of their practice and detailed in mainstream scientific literature their research findings on its effectiveness.57–59 Wells C, Kolt GS, Marshall P, Hill B, Bialocerkowski A. Effectiveness of Pilates exercise in treating people with chronic low back pain: a systematic review of systematic reviews. BMC Med Res Methodol. 2013;13:7. Available from:
Squat between putting away dishes. During repetitive physical activities such as putting away dishes or loading the dishwasher, throw in squat, lunge, or other repetitive exercise between each repetition. This way, you'll naturally end up doing repetitions of exercises that need to be performed in repetition. putting each dish away or in the dishwasher.
In addition to determining the optimal position from which to initiate an exercise based on the patient's related impairments and level of pain, exercise dosage and progression are important aspects of a rehabilitation program. Intervention details, such as number of repetitions and sets, exercise order, and work-to-rest ratios, should be tailored to each patient based on his or her specific needs. The proposed protocol does not describe a method to determine the initial exercise intensity or the criteria for modification or progression. Using a criterion-based method to determine the initial intensity and progression would individualize these guidelines of the exercise program. In their randomized controlled trial designed to address the effectiveness of exercises to treat RCIS, Lombardi et al6 used a 6-repetition maximum load to establish the starting intensity of strengthening exercises. They6 also recommended a reevaluation every 2 weeks to make necessary adjustments to exercise intensity. Although we do not know whether the 6-repetition maximum-load criteria used in their study is optimal, it is an excellent example of a criterion-based method to determine initial exercise intensity and progression. Future research on exercise for the treatment of RCIS should include criterion-based methods to determine the optimal exercise dosage and progression.

An evidence-based journal club of 9 faculty members and fellows reviewed the articles and extracted and tabulated the data. Individual outcomes for pain, range of motion (ROM), strength, and function were organized. Intragroup and between-groups outcomes were assessed for the effectiveness of treatment, and statistical outcomes were recorded when available. Clinical importance was determined when statistical value was P < .05 and the effect size or difference between treatments was 20% or more. Sixa major categories were created to organize the components of the physical therapy programs used in each study: ROM, flexibility and stretching, strengthening techniques, therapist-driven manual therapy, modalities, and schedule. Components from these categories were used to create a synthesized physical therapy program.
Jumping and throwing moves, punches, kicks, and swinging a club or a racket all require power, which comes from your core—and, yes, causes those ab muscles to cinch. "The core is the crossroads of your system, helping transfer force between your upper and lower body," says Rick Richey, a faculty member for the National Academy of Sports Medicine in New York City. Add medicine ball throws to your sets: A study in the Journal of Strength & Conditioning Research found they are ideal core strengtheners. (Don't just stop at tossing, medicine balls can be used for a full body workout.)
Choose 10 different exercises - For cardio, focus on exercises with different levels of intensity. For example, you might alternate a high-intensity exercise (such as jumping jacks or burpees) with an easier move (such as marching in place). For strength training, choose compound exercises such as squats, lunges, pushups and dips to work the entire body. Exercise ideas: Step by Step Cardio Exercises, Step by Step Body Weight Exercises
Stand with feet shoulder-width apart. Lift right leg straight back and up; at same time, hinge at waist and bring hands or fingertips to floor in front of left foot. Bend both knees, bringing right knee behind left knee. Press back up through left foot to return to previous position. Do 15 reps, keeping leg raised, then switch sides and repeat. Do 3 sets.

I love this product! The videos are entertaining, and very insightful. When you are doing the exercises it gives you good instructions on how to do the move and shows you different ways you can do if you aren't in the best of shape yet. I swear I am not that out of shape and I get so tired after 10 mins of working out. I love it. I lost 5 pounds within the first 2 weeks. I wasn't even trying hard. It tells you to do up to 3 video's a day if time permits or just the 1, and I only do 1 and have already seen results. Looser pants, slimming waist, and compliments from all my friends and family. I def would recommend this to anyone who has time restrictions, children who dont give you time to work out or just anyone looking to loose the few ... full review
For Paced Audio Workouts: MotionTraxx (iPhone or iPad) - This music-based app is another great option for home exercisers, particularly if you're a walker or runner. Deekron the Fitness DJ has put together an incredible variety of music mixes, all set at different beats per minute, so you can find the perfect pace for any workout - Walking, running, lifting weights or other activities. There are also coached workouts (these cost extra) available at iTunes.
^ Jump up to: a b Cooney GM, Dwan K, Greig CA, Lawlor DA, Rimer J, Waugh FR, McMurdo M, Mead GE (September 2013). "Exercise for depression". Cochrane Database Syst. Rev. 9 (9): CD004366. doi:10.1002/14651858.CD004366.pub6. PMID 24026850. Exercise is moderately more effective than a control intervention for reducing symptoms of depression, but analysis of methodologically robust trials only shows a smaller effect in favour of exercise. When compared to psychological or pharmacological therapies, exercise appears to be no more effective, though this conclusion is based on a few small trials.

Besides toning the muscles, Pilates is known for boosting endurance. A wall and small hand-weights are the only necessities for this highly effective exercise. Stand with your back against the wall and feet hip-width apart. Walk the feet out a little, bend the knees, and slide down as if sitting in a chair. Progress in intensity each day until you can get your upper legs parallel to the floor. Raise the arms to shoulder height and hold for 30 seconds. Do two reps.
You probably already spend one to three minutes brushing and flossing your teeth at least once a day. Why not brush your teeth while holding a deep squat, or while doing side leg lifts? These things are perfectly doable and add no additional time to your tooth-brushing activities. Simply tell yourself that you have no excuse for brushing your teeth without holding a deep squat. No matter how tired you are.

Jump up ^ Olsen CM (December 2011). "Natural rewards, neuroplasticity, and non-drug addictions". Neuropharmacology. 61 (7): 1109–1122. doi:10.1016/j.neuropharm.2011.03.010. PMC 3139704. PMID 21459101. Similar to environmental enrichment, studies have found that exercise reduces self-administration and relapse to drugs of abuse (Cosgrove et al., 2002; Zlebnik et al., 2010). There is also some evidence that these preclinical findings translate to human populations, as exercise reduces withdrawal symptoms and relapse in abstinent smokers (Daniel et al., 2006; Prochaska et al., 2008), and one drug recovery program has seen success in participants that train for and compete in a marathon as part of the program (Butler, 2005). ... In humans, the role of dopamine signaling in incentive-sensitization processes has recently been highlighted by the observation of a dopamine dysregulation syndrome in some patients taking dopaminergic drugs. This syndrome is characterized by a medication-induced increase in (or compulsive) engagement in non-drug rewards such as gambling, shopping, or sex (Evans et al., 2006; Aiken, 2007; Lader, 2008).
In line with the previous literature, our study showed that walking was the most common exercise type among older adults [24, 25]. This result is not surprising as walking is among the most cost effective and accessible means of exercise [26]. In addition, walking has been identified as a relatively safe exercise alternative to older adults [25]. We found that walking was the most common exercise type in both training groups. However, the MCT group had a higher proportion of walking sessions than the HIIT group, while the HIIT group had a higher proportion of sessions with for instance jogging and cycling. This might indicate that some older adults in the HIIT group feel that it is easier to achieve a high-intensity level when performing jogging and cycling compared to walking. Absolute workload at a given intensity varies greatly among individuals with different levels of cardiorespiratory fitness (CRF) [27], so that e.g. walking at 5 km/h corresponds to moderate intensity for an individual with relatively high CRF level, while the same speed exhibits near-maximal intensity for an individual with low CRF. Therefore, the type of exercise an individual need to perform in order to achieve a feeling of high intensity varies from one individual to another [27]. Since ageing often results in CRF decline [28], it is likely that many older adults will reach a feeling of high-intensity when walking. However, those with a high CRF level might need to perform other exercise types, for instance jogging and cycling, to reach the same intensity level during their workout session.
This research has revealed a forgotten chapter in recent history of physical rehabilitation, medicine, and sports. Independent MMB methods have enjoyed celebrated success since 1890 and the exercises have changed the lives of millions of individuals, from common citizens to athletic performers, celebrities and Royalty. The MMB methods have provided immense personal hope and also national pride, however, to date, they have not been communally recognized as an official clinical tool or as an independent sporting category. As the scope of this paper was limited to readily available published documents, resorting at times to third-source century-old information, it is hoped that the publication will instigate further investigations to the origins of MMB methods and the general history of movement-harmonizing exercises. As the six MMB pioneers were presented in this paper as part of a broad historic movement, it is expected that future research will expose multiple other like-minded exercise methods that were developed during the same era and in similar circumstances. This will provide current MMB educators and practitioners with a wealth of information and new angles of approach that remain applicable today. To support the official healthcare identification of MMB methods as an independent activity category besides aerobic training and weightlifting, high quality research through both prospective randomized and blinded investigations along with subsequent systematic reviews and meta-analysis will eventually be required. Standardized baseline measures and criteria will be needed with external standards including functional status outcomes and appropriate statistical analysis. As an independent category, the communal value of MMB methods can be validated scientifically and accepted as evidence-based healthcare.
2. The "For Dummies" series. Any of the "Dummies" series videos (like Shaping up with Weights for Dummies, Pilates for Weight Loss for Dummies and Basic Yoga for Dummies) are usually excellent, says Zurowski. These videos go slowly, explain the workout clearly, and show the exercise from multiple angles. The instructor is always alone, so there are no distractions. Another good feature of this series is that it also shows mistakes to avoid, says Glenna.
Exercise Videos and DVDs are a popular way people work out every day. There are a massive amount of exercise videos available that target all kinds of fitness goals. Trying to figure out which exercise videos are the best can be a real challenge. Our information can help. With all of the choices available is very easy to get overwhelmed and frustrated when you’re trying to figure out which videos are going to give you the results you are looking for. We’ve done a lot of research on the internet and studied professional fitness individuals and have compiled an exercise videos review that will take the guesswork out of which videos are the best and will help you narrow down the choices and decide on videos that will help you reach your goals.
Video Abstract for the ESSR 45.2 article “Joint Loading in Runners Does Not Initiate Knee Osteoarthritis” from author Ross H Miller. Runners do not have a greater prevalence of knee osteoarthritis (OA) than non-runners. The hypothesis that joint loads in running do not cause OA is forwarded. Two mechanisms are proposed: 1) cumulative load, which is surprisingly low in running, is more important for OA risk than peak load, and 2) running conditions cartilage to withstand the mechanical stresses of running.
I've always wanted to try out the trendy fitness classes at Physique 57 in NYC, but they run a pretty penny. Now, the infamous Physique 57 technique (certain muscles are targeted, overloaded to point of fatigue and then stretched for relief) is available to all in this 30-minute workout. It was just enough to make me realize why people are obsessed with the classes and left me — especially my glutes — sore the next day.
“The best exercise you can do if you only have 30 seconds each day is to learn and practice diaphragmatic breathing,” explains Carla Chickedantz, a personal trainer with Crunch gyms. “Diaphragmatic breathing is the most basic, original strength building technique that each and every human uses to build core strength as a newborn baby. As adults, we lose this skill and rely on auxiliary muscles in the chest, shoulders, and neck for respiration. This causes all sorts of problems. During our workouts, we often focus on the front, back and sides of the core, and neglect the top and bottom. Yes, the core is like a canister with the diaphragm at the top and pelvic floor at the bottom.”
Video Abstract for the ESSR 45.2 article “Joint Loading in Runners Does Not Initiate Knee Osteoarthritis” from author Ross H Miller. Runners do not have a greater prevalence of knee osteoarthritis (OA) than non-runners. The hypothesis that joint loads in running do not cause OA is forwarded. Two mechanisms are proposed: 1) cumulative load, which is surprisingly low in running, is more important for OA risk than peak load, and 2) running conditions cartilage to withstand the mechanical stresses of running.
Major variants: reverse ~ (curling the pelvis towards the shoulders), twisting ~ or side ~ (lifting one shoulder at a time; emphasis is on the obliques), cable ~ (pulling down on a cable machine while kneeling), sit-up ~ (have [chest] touch your knees), vertical crunch (propping up to dangle legs and pulling knees to the [ chest] or keeping legs straight and pulling up legs to a 90 degree position). Reverse hanging crunch (using gravity boots or slings to hang head down and pulling to a 90 or 180 degree form)
Jump up ^ Silverman MN, Deuster PA (October 2014). "Biological mechanisms underlying the role of physical fitness in health and resilience". Interface Focus. 4 (5): 20140040. doi:10.1098/rsfs.2014.0040. PMC 4142018. PMID 25285199. Importantly, physical exercise can improve growth factor signalling directly or indirectly by reducing pro-inflammatory signalling [33]. Exercise-induced increases in brain monoamines (norepinephrine and serotonin) may also contribute to increased expression of hippocampal BDNF [194]. In addition, other growth factors—insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor—have been shown to play an important role in BDNF-induced effects on neuroplasticity [33,172,190,192], as well as exerting neuroprotective effects of their own [33,214,215], thereby contributing to the beneficial effects of exercise on brain health.

“Chronological age is not a good indicator of biological age,” says Balachandran. “Some people who are in their 80s are as agile and vibrant as some in their 60s.” It’s not clear why, he notes. “But I think physical activity could be one overlooked factor.” The body deteriorates with time, yet how quickly and drastically those changes come may be largely up to you.
'Time exposed' to training, in both the intervention and control arms of the study, was defined as the length of time an individual spent in training with his or her original training group free of AKP. Patients were thus censored at the point they were removed from training (various time-points through the 14-week training period). Participants who successfully completed training with their original troop were censored at the point of exit (14 weeks). There was no follow-up after the 14-week point.
The other important part? It has to be tough — 85% or more exertion for 30-seconds to one minute, followed by a 10-second rest. Or, as Heather Tyler, an NSCA-certified personal trainer and owner of Simply Fit LA wrote to me in an email, “you know that feeling like you’ve run up five flights of stairs, your heart’s pounding in your ears, you’re dripping sweat and you sound like a donkey wheezing?”

Lose yourself in the high-energy rhythm of the Pound Rockout Results System, a five-disc sweatfest in which you wield drumsticks (aka Ripstix) instead of weights. "The drumming takes your mind off your muscles hurting!" one tester marveled. You'll "constantly tap the sticks" in each routine—core, upper body, lower body, intervals, tune-up and jam session—for a "totally unique" cardio blast.

One of the easiest parts of starting an exercise program is deciding to do it. Usually there's something inspiring you to make a change: Maybe you tried on a pair of jeans that were too tight or there's an upcoming event—a reunion, wedding, or party—where you're going to see people you haven't seen in a while. Whatever it is, you're motivated, you're excited, and the fantasy of a new, slimmer you is enough to inspire you.

The physical benefits of Pilates include an increase in muscle strength and tone without creating bulk. The increase in deep core muscle strength helps to make your abdominal muscles look tight and toned. It also improves your flexibility and posture, which can decrease your chances of injuring yourself. Pilates is also effective in easing chronic lower back pain and preventing future back pain and injuries.
Aerobic exercise induces short- and long-term effects on mood and emotional states by promoting positive affect, inhibiting negative affect, and decreasing the biological response to acute psychological stress.[45] Over the short-term, aerobic exercise functions as both an antidepressant and euphoriant,[46][47][48][49] whereas consistent exercise produces general improvements in mood and self-esteem.[50][51]
Here's how to do it with good form. Stand with feet shoulder-width apart, then bend knees and flex forward at the hips. (If you have trouble doing this exercise standing up, support your weight by sitting on an incline bench, facing backward.) Tilt your pelvis slightly forward, engage the abdominals, and extend your upper spine to add support. Hold dumbbells or barbell beneath the shoulders with hands about shoulder-width apart. Flex your elbows, and lift both hands toward the sides of your body. Pause, then slowly lower hands to the starting position. (Beginners should perform the move without weights.)
Here's how to do it with good form. Stand with feet shoulder-width apart, then bend knees and flex forward at the hips. (If you have trouble doing this exercise standing up, support your weight by sitting on an incline bench, facing backward.) Tilt your pelvis slightly forward, engage the abdominals, and extend your upper spine to add support. Hold dumbbells or barbell beneath the shoulders with hands about shoulder-width apart. Flex your elbows, and lift both hands toward the sides of your body. Pause, then slowly lower hands to the starting position. (Beginners should perform the move without weights.)

Matt Sauerhoff, owner of The LIV Method says one of his favorite, fastest and easiest to do on the go moves is the wall squat. “Start with your back against the wall and your heels about a foot off the wall. Bend your knees and slide down the wall until your legs create a 90-degree angle,” he says. “Make sure your knees are aligned over your toes/laces. Press heels into the floor and focus on contracting your abs, pressing lower back into the wall so it’s flat. Hold for 30 seconds.” Combine it with these 30 Fat-Burning Foods and you’ll be melting the fat in no time!

One of the foundational moves of any strength program is the back squat. The back squat is performed with a barbell across the trapezius muscles, feet a little wider than shoulder-width apart, and feet slightly turned out. HOW TO DO IT: Take a big breath to brace the core, then send your buttocks back while keeping your chest big and proud. You should squat below parallel if your mobility allows. As you drive up, think of screwing your feet out and into the ground. This cue will fire the glutes so that you can get the most strength out of the movement. MUSCLES USED: Glutes, quads, hamstrings, calves and core.

Remember, the real trick to getting stronger is to progressively move more and more weight, so keep in mind that these tricks and tips are meant to supplement that goal Fundamentals of resistance training: progression and exercise prescription. Kraemer, W.J., Ratamess, M.A. Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT, USA; MEdicine and Science in Sports and Exercise; 2004 Apr;36(4):674-88.. Try out some new techniques and bulldoze that training plateau like a beast. Have you tried any of these techniques? What techniques help you build strength? Tell us in the comments below!
It's important to note that you can spread your activity into intervals as short as 10 minutes. So if you have a very busy schedule, even doing three, 10-minute aerobic exercises per day, five days per week, will be sufficient. To get you started, here are the different types of exercise, how they benefit the body and what kind of activities they entail:

The hypothalamus is under the control of several “higher” brain centres and several neurotransmitters 13 known to play a major role in various neuroendocrine and behavioural functions, for example, activation of the HPA axis, feeding and locomotion.14 Therefore, the typical HPA axisrelated hormones cortisol, adrenocorticotrophic hormone (ACTH), prolactin (PRL) and human growth hormone (GH) were targeted in the present study.