In the fourth and final week of the program, you’ll train four days in a four-way split that hits each bodypart just once (except for calves and abs, which are each trained twice). Four-day splits are common among experienced lifters because they involve training fewer bodyparts (typically 2–3) per workout, which gives each muscle group ample attention and allows you to train with higher volume. As you’ll see, chest and triceps are paired up, as are back with biceps and quads with hamstrings, each a very common pairing among novice and advanced bodybuilders. Shoulders are trained more or less on their own, and you’ll alternate hitting calves and abs—which respond well to being trained multiple times per week—every other workout. No new exercises are introduced in Week 4 so that you can focus on intensity in your workouts instead of learning new movements.
In both groups, men had a higher proportion of cycling, cross-country skiing and jogging sessions compared to women (Fig. 4). Men also had a higher proportion of sessions with combined endurance and resistance training and domestic activities than women. In contrast, women had a higher proportion of walking, swimming and dancing sessions than men. There were no sex differences in resistance training and other types of endurance training (Fig. 4).

The exercises that Kuhn provided can be viewed as a partial list of exercises that might be appropriate for treating an individual with RCIS. We offer modifications to 3 of the proposed exercises and discuss factors used by athletic trainers and physical therapists to establish initial exercise selection, intensity, and periodic modification of an exercise program that were not discussed by Kuhn. Based on current evidence, the anterior shoulder stretch in the proposed protocol might not be the most effective way to stretch the pectoral muscles. When performing the stretch as described in the protocol, the individual is instructed to place his or her hands at shoulder level on either side of a door or corner and to lean forward. This might be a preferred position to initiate pectoral muscle stretch if the individual is unable to perform stretching with the arm elevated as a result of pain; however, evidence3 indicates that changing the position of the upper extremity so that the individual's hand is above the head with the shoulder in 90° of abduction and 90° of external rotation likely provides a more effective stretch.
Sometimes the terms 'dynamic' and 'static' are used.[citation needed] 'Dynamic' exercises such as steady running, tend to produce a lowering of the diastolic blood pressure during exercise, due to the improved blood flow. Conversely, static exercise (such as weight-lifting) can cause the systolic pressure to rise significantly, albeit transiently, during the performance of the exercise.[8]
This Chinese martial art that combines movement and relaxation is good for both body and mind. In fact, it's been called "meditation in motion." Tai chi is made up of a series of graceful movements, one transitioning smoothly into the next. Because the classes are offered at various levels, tai chi is accessible — and valuable — for people of all ages and fitness levels. "It's particularly good for older people because balance is an important component of fitness, and balance is something we lose as we get older," Dr. Lee says.
In Week 1 you’ll perform three sets of every exercise per workout, which over the course of the week adds up to nine sets total for each bodypart, a good starting volume for your purposes. With the exception of crunches for abs, you’ll do 8–12 reps per set. This rep scheme is widely considered ideal for achieving gains in muscle size (the scientific term is hypertrophy) and is commonly employed by amateur and pro bodybuilders alike.

To qualify for inclusion, studies had to be level 1 or level 2 (randomized controlled trials); had to compare rehabilitation interventions, such as exercise or manual therapy, with other treatments or placebo; had to include validated outcome measures of pain, function, or disability; and had to be limited to individuals with diagnosed impingement syndrome. Impingement syndrome was determined by a positive impingement sign per Neer or Hawkins criteria, or both. Articles were excluded if they addressed other shoulder conditions (eg, calcific tendinosis, full-thickness rotator cuff tears, adhesive capsulitis, osteoarthritis), addressed postoperative management, were retrospective studies or case series, or used other outcome measures.
Alicia Marie, celebrity trainer, says you can change your core with plank twist corkscrews. “Hold in low plank position, keeping your core muscles tight and your forearms flat,” she says. “Slowly rotate your hips to one side, being sure not to drop them to the floor, then rotate your hips back to center. With your core muscles still engaged, rotate to the opposite side. Alternate back and forth slowly, completing five reps on each side for a total of four sets.”
What if we told you that you could get a kick-ass cardio workout that would keep you on your toes, without even leaving the house? Better still: The steps are broken down into beginner, intermediate, and advanced levels, so you can adjust as needed. And the bodyweight-only moves are mostly low impact, meaning you can do them in the comfort of your own living room without worrying about annoying the downstairs neighbors.
Jump up ^ Bouchard J, Villeda SA (2015). "Aging and brain rejuvenation as systemic events". J. Neurochem. 132 (1): 5–19. doi:10.1111/jnc.12969. PMC 4301186. PMID 25327899. From a molecular perspective, elevated systemic levels of circulating growth factors such as vascular endothelial growth factor and insulin-like growth factor 1 (IGF-1) in blood elicited by increased exercise have been shown to mediate, in part, enhancements in neurogenesis (Trejo et al. 2001; Fabel et al. 2003).
Dietary nitrate supplementation increases circulating nitrite concentration, and the subsequent reduction of nitrite to nitric oxide is promoted in hypoxic environments. Given that PO2 is lower in Type II compared with Type I muscle, this article examines the hypothesis that the ergogenicity of nitrate supplementation is linked to specific effects on vascular, metabolic, and contractile function in Type II muscle.
The split jerk is a very powerful and fast move. HOW TO DO IT: The bar starts in the front rack position with your feet hip-width apart. Take a big breath to tighten your core, then dip straight down just a few inches to get more power. Next, drive the bar up overhead while splitting your legs into a lunge position. The goal is to get under the bar as fast as possible while driving the bar up overhead. MUSCLES USED: Glutes, quads, hamstrings, calves, core, shoulders, back and triceps.

Video Abstract for the ESSR 44.4 article “The Age-Associated Reduction in Propulsive Power Generation in Walking” from author Jason R. Franz. Propulsive power generation during push-off in walking decreases with advancing age. A common explanation is an accommodation for sarcopenia and muscle weakness. Yet, muscle strengthening often yields disappointing outcomes for walking performance. We examine the hypothesis that declines in force or power generating capacity of propulsive leg muscles cannot fully explain the age-related reduction in propulsive power generation during walking.
Around thirty years ago, Andersen et al. [10] developed a novel exercise model (i.e. one leg dynamic exercise, OLDE) allowing dynamic isotonic contractions of the knee extensor muscles. This exercise model isolates the knee extensor muscles via an active knee extension and passive knee flexion, and due to the reduced muscle mass involved, this exercise is not limited by cardiorespiratory function [11]. Therefore, this model was extensively used to investigate the effect of OLDE on the cardiorespiratory system (e.g. [12]), skeletal muscle physiology (e.g. [13]) but also with patients suffering from cardiorespiratory limitations [14, 15] or for studying mechanisms regulating circulatory response to rhythmic dynamic exercise [6, 16]. More recently, high intensity OLDE has been used to investigate CNS processes involved in the regulation of muscle fatigue and endurance performance [8, 11, 17, 18]. Despite being recently used to investigate muscle endurance, the reliability of high intensity OLDE has not been tested. Reliability can be defined as the consistency of a performance measure, and should be established for any new measurement tool [19, 20]. Furthermore, reliability of a protocol can be used to estimate the sample size required for an appropriate statistical power [20]. The main aim of this study was to establish the reliability of high intensity OLDE as a measure of muscle endurance. Additionally, as the sensitivity of a protocol reflects its ability to detect small changes in performance, we also calculated the smallest worthwhile change as a measure of sensitivity [21].

Video Abstract for the ESSR 46.2 article “Potential Role of MicroRNA in the Anabolic Capacity of Skeletal Muscle With Aging” from author Donato Rivas. Age-induced loss of skeletal muscle mass and function, termed sarcopenia, may be the result of diminished response to anabolic stimulation. This review will explore the hypothesis that alterations in the expression of microRNA with aging contributes to reduced muscle plasticity resulting in impaired skeletal muscle adaptations to exercise-induced anabolic stimulation.
A simple example of an eccentric contraction is to hold something in your hand with your elbow bent. Slowly allow your elbow to straighten out while holding the weight.  You can visualize your bicep muscle lengthening as you are holding the weight while you are slowly straightening your elbow.  This is an eccentric contraction or eccentric loading of your bicep muscle.

P corresponds to the power expressed in watt (W), T the torque in newton meter (N·m) and the angular velocity in rad/s. Typical recordings of torque, position and EMG signals from the Vastus Lateralis (knee extensor) and Biceps Femoris (knee flexor) could be found in Fig 2. Fig 2 presents all signals previously mentioned for an isotonic resistance of 9 N·m (~ 16.7 W, panel A) and 37 N·m (~ 68.5 W, panel B). The inactivity of the Biceps Femoris during the flexion phase confirms that we were successful in creating a protocol on the dynamometer that isolates the knee extensor muscles during dynamic exercise, as in the exercise model originally proposed by Andersen et al. [10].
Or should I say Chalene JAMS! This is a really fun program. I admit I felt kind of foolish and uncoordinated at first, but now that I know the moves I get in there and sweat up a storm! I like that there are low impact modifications for those of us with back or knee issues that preclude a whole lotta jumping around. I haven't lost any weight doing the program (probably more hormonal and metabolic roadblocks than lack of trying) but I feel better when I do it, so I am not disappointed one bit.
“Everyone can dance! Just embrace your style! And, if it’s for fitness, well, the point is to get you moving, not to be a professional! So, if you’re sweating and having a good time, you’re doing it right!” says Blogilates creator Cassey Ho. In this video, she takes you through a step-by-step, 14-minute dance cardio workout, complete with instructions. This video is great for those who need a bit of extra guidance. After you’ve learned the exercises, you may even be able to take a few of these moves to the floor.
Flexibility is a factor in yoga, but it is not a necessary for beginner classes. Continued practice over time will increase your agility and flexibility. You can see positive results over time even if you only attend an hour a week, but attending classes around 2-3 times per week will help you experience the most benefits. Yoga classes usually last around an hour from warm-up to cool down.
Bottom line. Strength training with heavy weights is a better way to target your glutes, but that’s not something most people will do. The program includes low- and high-impact routines, so you don’t need to be extremely fit to start. If you don’t mind doing lots of squats and lunges and you like the idea of dancing your way to fitness, this may be good for you. The Brazil Butt Lift eating plan includes basic recipes with easy variations.
Tabata training is a form of high-intensity interval training. It consists specifically of eight rounds of high-intensity exercise using a 20 seconds on (at full capacity) and 10 seconds off (rest) format. The goal is to push yourself as hard as you can during the 20 second on period. Tabata only requires one exercise, but you can combine different strength and aerobic exercises to make your own Tabata routine. Here’s a simple example of Tabata for one exercise:
In 1904, Danish prize-winning athlete and gymnastics educator JP Müller followed Checkley’s exercise philosophy with the publication of ‘My System’. This book described how the relatively healthy, average person could keep fit, fortify health and stamina, and increase physical and mental efficiency with 15 min of daily exercise. He claimed: ‘If people only knew how much more, how much better and how much longer they can enjoy life, instead of being controlled by a weakly body, they have a strong and healthy one at their command!’15 Müller JP. My system. London: Link House; 1904. [Google Scholar] Müller was born a weak child and developed an exercise routine to re-build his own body, inspired by the harmony of ancient Greek statues. His routine included exercising natural functional movements, self-massage of skin in fascial lines, exposure to the sun, and bathing in cold water in addition to running on the balls of the feet as an aerobic activity.15,16 Müller JP. My system. London: Link House; 1904.
As mentioned earlier, aerobic exercise is primarily characterized by activities that cause the heart to pump at an accelerated pace for an extended period of time. In addition to referring to activities that engages the heart, aerobic exercise refers to physical exercise that either improves or involves the body's oxygen consumption. When cardio exercise is used alongside a healthy diet and anaerobic exercise, it can contribute to a healthy life. Cardio is a particularly good category of exercise to perform in order to shed pounds, as cardio exercise burns fat as a fuel source. Fats, along with oxygen and carbohydrates, together form the fuel source used by all cells: adenosine triphosphate (ATP). For some aerobic exercise routines to get you started, check out this great list and this informative page.

“Chronological age is not a good indicator of biological age,” says Balachandran. “Some people who are in their 80s are as agile and vibrant as some in their 60s.” It’s not clear why, he notes. “But I think physical activity could be one overlooked factor.” The body deteriorates with time, yet how quickly and drastically those changes come may be largely up to you.
The other important part? It has to be tough — 85% or more exertion for 30-seconds to one minute, followed by a 10-second rest. Or, as Heather Tyler, an NSCA-certified personal trainer and owner of Simply Fit LA wrote to me in an email, “you know that feeling like you’ve run up five flights of stairs, your heart’s pounding in your ears, you’re dripping sweat and you sound like a donkey wheezing?”
In Week 1 you’ll perform three sets of every exercise per workout, which over the course of the week adds up to nine sets total for each bodypart, a good starting volume for your purposes. With the exception of crunches for abs, you’ll do 8–12 reps per set. This rep scheme is widely considered ideal for achieving gains in muscle size (the scientific term is hypertrophy) and is commonly employed by amateur and pro bodybuilders alike.
^ Jump up to: a b Wilkinson DJ, Hossain T, Hill DS, Phillips BE, Crossland H, Williams J, Loughna P, Churchward-Venne TA, Breen L, Phillips SM, Etheridge T, Rathmacher JA, Smith K, Szewczyk NJ, Atherton PJ (June 2013). "Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism" (PDF). J. Physiol. 591 (11): 2911–2923. doi:10.1113/jphysiol.2013.253203. PMC 3690694. PMID 23551944. Retrieved 27 May 2016.
The physical benefits of Pilates include an increase in muscle strength and tone without creating bulk. The increase in deep core muscle strength helps to make your abdominal muscles look tight and toned. It also improves your flexibility and posture, which can decrease your chances of injuring yourself. Pilates is also effective in easing chronic lower back pain and preventing future back pain and injuries.

Vinylcise has been historically neglected, and probably for good reason: it's terrible, and not very effective—at least not since we've had visual media alternatives. Can you imagine trying to follow along to an audio-only workout? At any rate, these workout records first appeared in the early 1920s, and were usually accompanied by a paper foldout with exercise diagrams (see the image). The earliest of these records appear to be the set of five Wallace Reducing Records released in 1920-1922 by the Wallace Institute of Chicago and pressed by Columbia Records. These records were marketed towards women, aiming to help them "get thin to music." Other exercise records of the 1920s included Victor Records for Health Exercises, released in 1922, the Battle Creek Sanitarium Health Ladder, directed by John Harvey Kellogg and released by Columbia Records in 1923, and Walter Camp's Daily Dozen, released in 1924.
Katy Fraggos, co-Owner and Head Trainer at Perspirology, says you can work your triceps, core, hip flexor, working leg quadriceps, and supporting leg hamstring in just 30 seconds a day with this move. “Start with your hands behind your back on the floor with fingertips pointed in. Working leg lifted with flexed foot. Butt is off the floor,” she says. “When elbows are bent, the knee is pulled into the chest. Arms will straighten as leg kicks outward to the front of the body in a ‘pumping’ action.” Try to complete as many as possible in 30 seconds and then if you have extra time, repeat for 30 seconds with the opposite leg lifted.
Static Hold. Static holds are familiar to some as a great strengthening technique used in yoga. They can be performed with bodyweight movements — get in the top of a plank or a deep squat position and hold — or they can be done by holding weights (in a slightly contracted position or with full lock out). Our tip? Time how long you can hold a plank to see improvement from week to week.
Where did we come up with the moves? Well, we tapped Josey Greenwell, certified trainer and Barry's Bootcamp instructor, to show us some of his favorite heart-pumping exercises. You can create your own routine by following our guidelines—or try his workout at the end of the article. Either way, you'll be burning fat and upping your cardiovascular endurance—win-win!
Don’t blink or you just might miss this seven-minute, high-energy dance workout with Vixen Dance for Elle.com. Featuring Janet, Shanut, and Carolina, this dance cardio session will have you sweating in no time. The Vixen Workout website describes its style as “a dance fitness format that uses commercial choreography, killer music remixes, and stage lighting so you can experience yourself as a performer.” This fast-paced routine will definitely burn some calories.
After 5 min warm up at 20% of peak power output, subjects performed a time to exhaustion at 85% of peak power output. Exhaustion was defined as a decrease in cadence below 40 cpm for a duration ≥ 10 s or when the subject voluntarily stopped. Subjects were not aware of the time elapsed during the time to exhaustion test. Verbal encouragements were provided by an experimenter naïve of time to exhaustion during the previous sessions.

I purchased Insanity a few years back and only lasted for 3-4 workouts. The workouts were too difficult for me and although I enjoyed it, I just failed to commit to it. Fast forward to July of this year..... I am not even sure why I attempted it again, but I am glad I did. First things first; this program is physically challenging to the point that I would recommend anyone going into it be cleared by their doctor BEFORE starting. Seeing a physician after you've injured yourself is the equivalent of closing the barn after the horses got out! There, it's been said. Now on to my review of this product.


CrossFit Games: The sport of fitness has arrived (or so claims Reebok, the official sponsor of the CrossFit Games). Each summer the CrossFit Games test participants with a barrage of physical challenges and workouts, ranging from swimming and running to pull-ups and handstand walks (sorry, Kobayashi, hot-dog eating has yet to make an appearance). Participants accrue points over the events, and the male and female winners are crowned World’s Fittest Man & Woman. Sectional and Regional qualifiers narrow the field before the annual Games Weekend.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

We not only offer a superior training protocol, SMX also uses state-of-the-art training tools. The majority of our equipment is MEDX Rehabilitative Exercise Equipment, one of the most respected and technologically-advanced fitness, sports, and medical/rehabilitation equipment brands. MedX products are developed through decades of experience and millions of dollars in independent, university-based research. MedX equipment achieves training efficiency through resistance curves matched to tested and proven strength profiles. They operate at a very low level of friction and offer a choice of resistance in 2-pound increments, ensuring a weight that is just right – not too heavy and not too light – for rapid and steady progress. We have also incorporated select Nautilus equipment. Nautilus is considered the gold standard in fitness and a cornerstone of the modern commercial gym.


In total, 1567 participants (790 women) met the inclusion criteria, fulfilled baseline testing and were randomized 1:1 into an exercise training group or to a control group. The exercise training group was further randomized 1:1 to either MCT or HIIT. Participants in the exercise groups were instructed to fill in exercise logs after each exercise session they performed. Data in the present study is based on the exercise logs from the first year of the intervention. Therefore, only participants in the exercise groups were included in the present study (n = 787). Dropouts in the exercise groups during the first year (n = 123) and those with no exercise logs (n = 46) were excluded. A total of 618 participants (291 women) were included in the analyses (Fig. 1). The study was approved by the Regional Committee for Medical Research Ethics (REK sør-øst B: 2015/945) and all participants gave their written informed consent before participation.
Regular aerobic exercise improves symptoms associated with a variety of central nervous system disorders and may be used as an adjunct therapy for these disorders. There is clear evidence of exercise treatment efficacy for major depressive disorder and attention deficit hyperactivity disorder.[43][48][52][53][54][55] The American Academy of Neurology's clinical practice guideline for mild cognitive impairment indicates that clinicians should recommend regular exercise (two times per week) to individuals who have been diagnosed with this condition.[56] Reviews of clinical evidence also support the use of exercise as an adjunct therapy for certain neurodegenerative disorders, particularly Alzheimer’s disease and Parkinson's disease.[57][58][59][60][61][62] Regular exercise is also associated with a lower risk of developing neurodegenerative disorders.[60][63] A large body of preclinical evidence and emerging clinical evidence supports the use of exercise therapy for treating and preventing the development of drug addictions.[64][65][66][67][68] Regular exercise has also been proposed as an adjunct therapy for brain cancers.[69]

2. The "For Dummies" series. Any of the "Dummies" series videos (like Shaping up with Weights for Dummies, Pilates for Weight Loss for Dummies and Basic Yoga for Dummies) are usually excellent, says Zurowski. These videos go slowly, explain the workout clearly, and show the exercise from multiple angles. The instructor is always alone, so there are no distractions. Another good feature of this series is that it also shows mistakes to avoid, says Glenna.
As you strengthen your abs, it's vital to tone the back of the body as well. Lie on your back with your knees bent and your feet hip-width apart. Keep your arms at your sides and raise your hips without arching your back. Tighten the muscles of your buttocks and hamstrings, and hold for five breaths. Lower down one vertebra at a time to the floor if you're stopping here, or go on to the advanced posture.
Rotator cuff impingement syndrome (RCIS) is a multifactored disease that can lead to functional limitations and an inability to participate in work, leisure, and sporting activities. This syndrome can be caused by many factors, such as weakness of the rotator cuff and periscapular muscles, decreased pectoral and rotator cuff muscle flexibility, abnormal motion patterns, extrinsic factors (eg, vibration exposure, use of hand tools, work-station height), and trauma. Kuhn provided a valuable synopsis of randomized controlled clinical trials in which the benefit of exercise for individuals with RCIS was examined. Substantial evidence1 exists to support the use of exercise for the management of this patient population. In addition, manual therapy has been shown1 to augment the effectiveness of exercise. However, we believe it is premature to label the proposed rehabilitation protocol as a criterion standard because of the lack of specific exercise descriptions, variability in the exercise programs, and inability to separate the effects of specific exercises on the measured outcomes that Kuhn noted. Furthermore, because RCIS is multifactored, use of the same exercise protocol to treat everyone with RCIS might not be the best standard of care.
At the twilight of his career, despite his personal success and loyal group of followers, Pilates was disappointed his philosophy was not adopted by all. However, a group of his followers became recognized mind–body educators in their own right. His dream was realized by them in the 1980s, when Contrology moved into and has since remained within mainstream acceptance and popularity as ‘Pilates.’39,42 Balanced Body, Inc. [Internet]. Origins of Pilates. 2015 Aug 30 [cited 2015 Aug 30]. Available from: https://www.pilates.com/BBAPP/V/pilates/origins-of-pilates.html.
Sometimes the terms 'dynamic' and 'static' are used.[citation needed] 'Dynamic' exercises such as steady running, tend to produce a lowering of the diastolic blood pressure during exercise, due to the improved blood flow. Conversely, static exercise (such as weight-lifting) can cause the systolic pressure to rise significantly, albeit transiently, during the performance of the exercise.[8]
For this basic strength-training workout, you'll do 1 set of 15 reps of each of the nine exercises listed below, resting briefly between exercises as needed. The workout targets all the muscles in the body, including the chest, shoulders, arms, back, hips, glutes, and thighs. It's short and simple—a great way for beginners to get started with strength training. 
Here's how to do it with good form. Stand with feet shoulder-width apart, then bend knees and flex forward at the hips. (If you have trouble doing this exercise standing up, support your weight by sitting on an incline bench, facing backward.) Tilt your pelvis slightly forward, engage the abdominals, and extend your upper spine to add support. Hold dumbbells or barbell beneath the shoulders with hands about shoulder-width apart. Flex your elbows, and lift both hands toward the sides of your body. Pause, then slowly lower hands to the starting position. (Beginners should perform the move without weights.)
Video Abstract for the ESSR 44.4 article “The Age-Associated Reduction in Propulsive Power Generation in Walking” from author Jason R. Franz. Propulsive power generation during push-off in walking decreases with advancing age. A common explanation is an accommodation for sarcopenia and muscle weakness. Yet, muscle strengthening often yields disappointing outcomes for walking performance. We examine the hypothesis that declines in force or power generating capacity of propulsive leg muscles cannot fully explain the age-related reduction in propulsive power generation during walking.
First, a disclaimer: I have no financial stake in the sale of any of the other books mentioned below in my review of "Superslow: The Ultimate Exercise Protocol". I'm just interested in promoting safe, logical, scientifically sound methods for people that care about being in good physical condition without any unnecessary risks or wasted time. Any other books or authors mentioned are merely for the purpose of expanding the information available regarding the history (and refinements) of High Intensity Training (HIT) since Arthur Jones first began to popularize the method in the early 1970's.
Recruiting lasted 6 months starting from September 2013. Participants were recruited by means of family doctors to whom the goal of the study was explained. The recruitment flow chart is shown in Figure 1. Three hundred and fifty people aged ≥ 65 were invited to participate. Of these, 51.4% agreed to be included in the screening list while 48.6% refused to participate, mainly for family reasons such as illness/hospitalization/old age of a family member. Forty people were found eligible to participate in the research protocol. Randomly, twenty were assigned to VE and twenty to the control group. The latter were instructed not to take part in any physical activity throughout the study period. All the selected participants signed an informed consent. The study was performed according to the Declaration of Helsinki and approved by the local ethics committee on September 23, 2013.
×