Sensitivity of ACTH and PRL for the detection of OTS was four out of four and five out of five, respectively (table 2; cutoff, 200% at the second exercise test) and for the detection of NFO was four out of five and three out of three, respectively. Sensitivity of cortisol (cutoff, 200% at the second test) and GH (cutoff, 1000%) for the detection of OTS was four out of five and two out of five, and for the detection of NFO, one out of five and two out of four, respectively (table 2).


Simply put, progressive overload means that you are consistently lifting or pulling a little more each week (or progressively on a schedule that aligns with your capacity). Lifting weight will break down your muscles. However — and this is where the magic happens — when the muscles grow back, they grow back stronger, but only if you are subjecting them to progressive overload.
Exercise tests were performed on a cycle ergometer (Lode Excalibur Sport, Groningen, The Netherlands) or on a treadmill (Ergo ELG 55; Woodway, Weil am Rhein, Germany) depending on the sport. Tests on the cycle ergometer started with an initial workload of 80 W (subjects 6 and 7) or 30 W (subjects 4 and 9), the workload was increased by 40 W every 3 min. Tests on the treadmill started at 5.4 km h−1, the speed was increased with 1.8 km h−1 each 3 min (subjects 1, 2, 3, 8 and 10). One subject performed the treadmill test with an inclination of 1% (subject 5). The duration of each test was recorded in seconds. Subjects wore a heart rate monitor (Polar Accurex Plus, Kempele, Finland) for determination of maximal heart rate (HRmax) throughout the exercise tests. After each exercise test, 20 μl of blood was drawn from the right earlobe to determine maximal blood lactate concentration ([La]max) with enzymatic analysis (EKF; Biosen 5030, Barleben, Germany).

Strength (or “weight”) training exercises build muscle. One’s body naturally grows muscle until the age of 25. As we age, our body progressively loses muscle— unless you make an effort to maintain or build it. Strength is good for everyone, regardless of gender or age and helps in everyday activities. Muscle mass can significantly decrease your chances of obesity, diabetes, cancer, and osteoporosis. Gender does not affect one’s ability to grow muscle, but men can develop more muscle mass than women because men naturally have a higher percentage of lean muscle. Women, you will not turn into the Incredible Hulk by strength training — I say this because many women don’t do strength training out of a fear of getting “big.” I wish it were that easy!
Recruiting lasted 6 months starting from September 2013. Participants were recruited by means of family doctors to whom the goal of the study was explained. The recruitment flow chart is shown in Figure 1. Three hundred and fifty people aged ≥ 65 were invited to participate. Of these, 51.4% agreed to be included in the screening list while 48.6% refused to participate, mainly for family reasons such as illness/hospitalization/old age of a family member. Forty people were found eligible to participate in the research protocol. Randomly, twenty were assigned to VE and twenty to the control group. The latter were instructed not to take part in any physical activity throughout the study period. All the selected participants signed an informed consent. The study was performed according to the Declaration of Helsinki and approved by the local ethics committee on September 23, 2013.
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