Video Abstract for the ESSR 45.4 article “Mechanisms Associated With Physical ActivityBehavior: Insights From Rodent Experiments” from authors Michael D. Roberts, Gregory N. Ruegsegger, Jacob D. Brown, and Frank W. Booth. Dopaminergic signaling differences in the nucleus accumbens (NAcc) seemingly predispose rats to adopt different physical activity behaviors. Physical activity behavior also may be regulated through peripheral mechanisms (i.e., muscle and fat derived as well as hormonal signals). We hypothesize that physical activity behavior is regulated by the convergence of central and peripheral mechanisms onto the NAcc.

The benefits of exercise have been known since antiquity. Dating back to 65 BCE, it was Marcus Cicero, Roman politician and lawyer, who stated: "It is exercise alone that supports the spirits, and keeps the mind in vigor."[143] Exercise was also seen to be valued later in history during the Early Middle Ages as a means of survival by the Germanic peoples of Northern Europe.[144]

This is so that every muscle in your body can be targeted. Also, it provides variation so that you don't get bored and give up. If you don't like exercise, revert to what your ancestors did instead and walk everywhere, move constantly and do plenty of physical work at least once a day, such as chopping wood, gardening, carry loads or cleaning your house vigorously.

Exclusion criteria included major diseases or conditions such as severe heart disease, uncontrolled hypertension, obesity, osteoarticular pathology, and neurological disease. Criteria were evaluated on the basis of clinical history, resting ECG, and physical examination. Participants maintained their lifestyles and were instructed not to take part in any other physical programs throughout the study. At the time of the initial design, the study consisted of a 12-week randomized controlled trial with a frequency of 3 times a week, 36 sessions in all, ending with a new assessment of their wellness and the potential persistence of the results on functional/physical capacities.