Physical activity is beneficial for young people, who are naturally primed to soak up its rewards. The reality is that the majority of today’s youths, however, fall into one of two camps: Either they are athletes, engaging in one or many sports (as well as auxiliary training such as weightlifting and agility work, which can help create lifelong fitness habits) or they are sedentary.

A compound exercise is a move that incorporates multiple muscle groups, like lunges, deadlifts, and squats. It may also refer to two moves being strung together, like a bicep curl to a shoulder press. Compound exercises are efficient for increasing overall muscle mass and burning calories (because they require more effort to complete), as opposed to isolation exercises, which focus on working just one muscle group (like a bicep curl).
4) The schedule of workouts, while ideal for those in good shape, is a bit too aggressive for most. Your muscles NEED rest (and proper nutrition) to recover and become stronger. The calendar given provides only 1 day per week to rest. You may find you need more, especially early on while you are using and building new muscles. Modifiy and listen to your body accordingly.

Jump up ^ Rao AK, Chou A, Bursley B, Smulofsky J, Jezequel J (January 2014). "Systematic review of the effects of exercise on activities of daily living in people with Alzheimer's disease". Am J Occup Ther. 68 (1): 50–56. doi:10.5014/ajot.2014.009035. PMC 5360200. PMID 24367955. Alzheimer’s disease (AD) is a progressive neurological disorder characterized by loss in cognitive function, abnormal behavior, and decreased ability to perform basic activities of daily living [(ADLs)] ... All studies included people with AD who completed an exercise program consisting of aerobic, strength, or balance training or any combination of the three. The length of the exercise programs varied from 12 weeks to 12 months. ... Six studies involving 446 participants tested the effect of exercise on ADL performance ... exercise had a large and significant effect on ADL performance (z = 4.07, p < .0001; average effect size = 0.80). ... These positive effects were apparent with programs ranging in length from 12 wk (Santana-Sosa et al., 2008; Teri et al., 2003) and intermediate length of 16 wk (Roach et al., 2011; Vreugdenhil et al., 2012) to 6 mo (Venturelli et al., 2011) and 12 mo (Rolland et al., 2007). Furthermore, the positive effects of a 3-mo intervention lasted 24 mo (Teri et al., 2003). ... No adverse effects of exercise on ADL performance were noted. ... The study with the largest effect size implemented a walking and aerobic program of only 30 min four times a week (Venturelli et al., 2011).

Planks are a quadruple threat, and by holding one for just 30 seconds a day, you will instantly start seeing results on your abdominal muscles, arms, triceps, and core. Riggins suggests doing low and high planks for 30 seconds each. For the low plank, he says to “get up on your elbows and your feet like a push-up position. You can modify by getting on your knees and hold for 30 seconds.” For the high plank do the same but “hold your legs straight” for 30 seconds. If abs are your problem area, don’t miss our helpful article Can’t Get Cut Abs? A Celeb Trainer Explains Why!
Trainer Sara Haley loves 30 seconds a day of a core building exercise called resistance fight, which is especially great for those who’ve had children. “Lie on your back and lift one leg up to tabletop so that your knee is in line with your hip. Take your opposite hand and push against your thigh,” she says. “As you try to push your leg away with your hand, resist by pushing your leg into your hand in opposition. While all this is happening, you should be focusing on pulling your navel towards your spine and closing your rib cage. You may feel your body start to shake.” Be sure to hold for 15 seconds on each side. If your ears perked up at the mention of this being a great move for moms, then make sure you also look out for your kiddos with our report on 13 Scary Ingredients in Your Kid’s Lunch Box, Exposed!.
This Chinese martial art that combines movement and relaxation is good for both body and mind. In fact, it's been called "meditation in motion." Tai chi is made up of a series of graceful movements, one transitioning smoothly into the next. Because the classes are offered at various levels, tai chi is accessible — and valuable — for people of all ages and fitness levels. "It's particularly good for older people because balance is an important component of fitness, and balance is something we lose as we get older," Dr. Lee says.
The purpose of this paper is to investigate the history, origins, and influences of Western MMB training, to raise healthcare stakeholders’ awareness of this type of training and to initiate the consideration of official acceptance of MMB methods as an independent exercise category alongside aerobic training and weightlifting. This would provide decision-makers and individuals with new tools to prescribe optimal exercise combinations for remedial purposes, prevention of pathologies, and obesity as well as general health and performance enhancement. Significantly, these are the major factors that facilitate a regular active lifestyle.
Sometimes the terms 'dynamic' and 'static' are used.[citation needed] 'Dynamic' exercises such as steady running, tend to produce a lowering of the diastolic blood pressure during exercise, due to the improved blood flow. Conversely, static exercise (such as weight-lifting) can cause the systolic pressure to rise significantly, albeit transiently, during the performance of the exercise.[8]
Chase Squires is the first to admit that he's no fitness expert. But he is a guy who used to weigh 205 pounds, more than was healthy for his 5'4" frame. "In my vacation pictures in 2002, I looked like the Stay Puft Marshmallow Man at the beach," says the 42-year-old Colorado resident. Squires decided enough was enough, cut out fatty food, and started walking on a treadmill. The pounds came off and soon he was running marathons -- not fast, but in the race. He ran his first 50-mile race in October 2003 and completed his first 100-miler a year later. Since then, he's completed several 100-mile, 50-mile, and 50k races.
Shapiro recommends elevated quadrupled shoulder adduction for a total body workout. “Start on the floor on all fours with your knees on the ground shoulder width apart and hands on the ground shoulder width apart. Make sure your knees are in line with your hips and wrists in-line with your shoulders. Tuck your toes towards your body and straighten out your back to have a neutral posture,” he explains. “Here’s the fun part: now lift your knees off the ground just two to four inches. You should feel your arms, shoulders, core, quads, and legs shaking.” And for the finale? Utilize the back—begin by pushing your upper back to the sky, separating your shoulder blades. Immediately push your chest down to pinch your shoulder blades together to target the upper back muscle groups that include the rhomboids and lower traps.

Many exercise interventions have been conducted under controlled laboratory conditions [9], but we do not know how older adults prefer to exercise when they are not under controlled settings and are free to choose type, location and social setting (e.g. alone vs. together with others) of exercise. Furthermore, it has been shown that high-intensity interval training (HIIT) can induce superior changes in health-related markers compared to continuous moderate-intensity training (MCT) [10–13], also in older adults [14, 15]. The scientific interest in HIIT has greatly increased during recent years [9], but larger and longer studies under free-living conditions are needed to investigate whether HIIT is feasible as a public health strategy among older adults [9, 16]. Therefore, detailed information about older adults exercise patterns with MCT versus HIIT outside laboratory conditions is of particular interest.
Fran: Don't let the sweet name fool you. Perhaps CrossFit’s most famous workout, Fran is a 21-15-9 rep scheme of thrusters (95 pounds for men, 65 for women) and pull-ups. For those keeping track at home, that’s 21 thrusters and 21 pull-ups, followed by 15 thrusters and 15 pull-ups, and so on. Elite CrossFitters can finish this monstrosity in less than three minutes, but don’t expect to break twice that during the first try.
I enjoyed your functional training exercises, but I’m not sure about some of them as I was recently diagnosed with a small tear in my rotator cuff. I’m not planning on having surgery. My doctor said that I could work out, but other than saying not to do straight bar bench presses, he said if it hurts, don’t do it. I would love a little more direction than that. Do you have anything more to offer? Thank you.

Strength conditioning. Start by doing one set of exercises targeting each of the major muscle groups. Bryant suggests using a weight at which you can comfortably perform the exercise eight to 12 times in a set. When you think you can handle more, gradually increase either the weight, the number of repetitions, or number of sets. To maximize the benefits, do strength training at least twice a week. Never work the same body part two days in a row.
Did you know that there are actually four types of exercise, all of which serve varied purposes? Everyone knows that routine exercise is very important for healthy adults for varied functions, including bone and muscle strength, weight-loss or weight maintenance, heart health and even cognitive health. But there are four different types of exercise: Aerobic (or endurance), strength, flexibility and balance.
The Bloom Method is a unique system that is based on solid evidence compiled by our founder through her years of working individually with thousands of women in pregnancy, early post birth and well into motherhood. The Bloom Method combines cutting edge-core techniques, breathing practices, functional [mom] movements, strength training, Lagree [pilates] based moves, HiiT [for postnatal moms] and groundbreaking philosophies into one life-changing exercise method. 
There’s a simple way to get your body back in fat-blasting mode: Temporarily ditch your go-to moves. "When you change up your workout, your body works harder because it’s in unfamiliar territory," explains Amy Dixon, a Santa Monica, California–based trainer and exercise physiologist. "That’s what causes it to burn more calories and build more muscle."
Often, when you watch someone lifting weights in a gym, you’ll notice they’re essentially “throwing” the weights up and “dropping” the weights down more than actually “lifting” or “lowering” the weights. They’re allowing certain aspects of physics (momentum, inertia, and gravity) to do much of the work for them instead of truly engaging, and therefore stimulating their muscles. Unfortunately their “perceived” goal is to make the weight move, but the real goal in weight training isn’t just moving the weight; the goal is to fatigue and challenge the targeted muscles. Depending on the specific exercise and range of movement involved, we instruct our clients to take approximately 10 seconds to lift the weight and another 5-10 seconds to lower the weight. By moving slowly, you’re not allowing inertia to carry the weight up or using gravity to let the weight crash down during the lowering phase of the movement. This enhanced and more complete muscle fiber stimulation ensures that you’re not simply “spinning your wheels.” This high-quality exercise stimulus will lead to greater results far quicker than more traditional lifting methods.
Around 1900, Tasmanian-born Australian professional reciter and theatrical producer Frederick Alexander developed a novel methodology to harmonize full-body functional movements. As a child, Alexander suffered respiratory ailments, leading to the initial purpose of developing the method – to normalize his personal voice function in order to materialize a stage performance dream. In 1902, Alexander established the Sydney Dramatic and Operatic Conservatorium and in 1904, moved to London to spread his teaching method. During the first years, Alexander focused on teaching ‘full chest breathing’ techniques mainly to stage artists and people with breathing pathologies.19 Staring J. Frederick Matthias Alexander 1869-1955. The Origins and History of the Alexander Technique. A medical historical analysis of F.M. Alexander’s life, work, technique, and writings. Nijmegen: Radboud Universiteit; 2005. [Google Scholar] However, he soon discovered that retrieving the natural ‘conscious control’ via mindful postures and movements resulted in benefits not only for the vocal health and performance but also the health and performance of the whole body and mind.20 Alexander FM. Man's supreme inheritance. London: Methuen; 1910. [Google Scholar] This holistic evolvement transformed the newly formed ‘Alexander Technique’ into a general remedy and preventative tool suitable for all populations. Alexander explained in his 1910 book ‘Man’s Supreme Inheritance:’20 Alexander FM. Man's supreme inheritance. London: Methuen; 1910. [Google Scholar]
I created The Bloom Method with a desire to empower women before, during and after pregnancy. As a Pre & Postnatal Exercise Specialist, Core Rehabilitation Specialist and Pre and Postnatal Holistic Health Coach, I strive to provide women with empowering tools to help support your pregnancy, empower you during birth, prevent common pregnancy-related issues such as Diastasis Recti, Pelvic Floor Incontinence, and Prolapse. My clients that have experienced my methods experience a quicker healing phase post-baby.
Outdoors in nearby area and in nature was the most frequently reported exercise location in both training groups. This finding is in line with previous studies reporting that older adults prefer to exercise close to home [23, 30] and outdoors [23]. Interestingly, outdoors was the most common exercise location in both warmer and colder months despite the fact that colder months in Norway consist of more snow, higher prevalence of ice and relatively fewer hours of daylight compared to warmer months. The HIIT group had a higher proportion of sessions at a gym and sport facility compared to the MCT group. This finding is likely related to the fact that the HIIT group reported a higher proportion of sessions with exercise types commonly performed at these locations (e.g. swimming and other types of endurance training) compared to the MCT group. Some older adults might feel that it is easier to reach a high-intensity level with activities located at a gym and sports facility compared to outdoors.

If you want to form a gym habit, it can be difficult to know what to do or how to workout. Once you become immersed in exercise, it can feel like there’s not enough time to try all the different things! Plain and simple, this is just a knowledge gap. Learning how to workout is like learning anything else, it requires time, research and study. Hiring a personal trainer is the fastest route around this, but it also helps to be a “student of the game” by continuing to educate yourself.
Zumba Fitness-Concert Live. Ever been to a concert and just danced around with abandon? This Zumba video is the next best thing and it’ll count as a workout! In addition to the cardio burn, you’ll feel all the electricity from the crowd during this 70-minute latin dance workout. The video features 16 high-energy, calorie-blasting routines that you can do all at once, or pause and break up into intervals.
In his homeland of Denmark, Müller was a controversial figure. Some conceived his liberal philosophy and promotion of exposing the entire body to the sun to be anti-Lutheran and even pornography. During the last few years of his life, Müller returned to Denmark and vigorously promoted a natural ‘healing spring’, causing further resentment for being perceived as over-spiritual. After Müller’s death in 1938, a memorial bronze statue was erected by the Danish Government, however, he is since mostly forgotten by the general public (Figures 2–4).18 Larsen J. [Internet]. J.P. Muller, a Danish sportsman, world famous – and forgotten. 2015 Aug 30 [cited 2015 Aug 30]. Available from: [Google Scholar]

Bottom line. Muscle confusion is a snappy term for non-linear periodization, which simply means rotating the workouts you do so that your muscles are constantly challenged and you get better, faster toning and weight-loss results. Research suggests this approach is more effective than doing the same exercise routine. P90X is a 90-day plan that combines strength moves, cardio, and yoga­—and if you follow it faithfully, you will probably see results. But it’s suitable only for those who are already very fit because the routines are intense and take about an hour a day. Note: You’ll also need dumbbells, exercise bands, and a pull-up bar, which do not come with the basic system. The diet is complicated, but it provides an appropriate number of calories for the work you’ll be doing.
Here's a way to tone the thighs and butt without a reformer. Begin by kneeling. Lean to the left, placing your left hand on the mat under the shoulder and your right hand behind the head with the elbow pointing up. Raise your right leg until it is parallel to the floor. Holding the torso steady, kick the leg to the front and then to the back, knee straight. Do five reps on each side.
I must confess: the title of this section is misleading, because while most of us associate the first home workouts with fitness icons Jane Fonda and Richard Simmons, they were not the first ones to bring workouts inside our homes. In fact, before there were VHS tapes, before there were even televised workouts, there were the audio-only vinyl record workouts, nicknamed vinylcise.
Your body has that whole breathing thing on lock, but there's more than one way to inhale and exhale and some require extra work from the abs. "Kapalabhati breathing engages the transverse abdominis to push out the breath," says Allison Candelaria, owner of Soul Yoga in Oklahoma City. Here's how to do it: Sit tall, then strongly and quickly pull your navel toward your spine. Then release your ab muscles, forcing you to exhale. Work up to doing that 20 times, inhaling and letting your belly expand between each "pump." (This belly bonfire breathing technique can also help you fire up your body anywhere, anytime.)
Twelve normal men performed 1-min incremental exercise tests to exhaustion in approximately 10 min on both treadmill and cycle ergometer. The maximal O2 uptake (VO2 max) and anaerobic threshold (AT) were higher (6 and 13%, respectively) on the treadmill than the cycle; the AT was reached at about 50% of VO2 max on both ergometers. Maximal CO2 output, heart rate, and O2 pulse were also slightly, but significantly higher on the treadmill. Maximal ventilation, gas exchange ratio, and ventilatory equivalents for O2 and CO2 for both forms of exercise were not significantly different. To determine the optimum exercise test for both treadmill and cycle, we exercised five of the subjects at various work rate increments on both ergometers in a randomized design. The treadmill increments were 0.8, 1.7, 2.5, and 4.2%/min at a constant speed of 3.4 mph, and 1.7 and 4.2%/min at 4.5 mph. Cycle increments were 15, 30, and 60 W/min. The VO2 max was significantly higher on tests where the increment magnitude was large enough to induce test durations of 8-17 min, but the AT was independent of test duration. Thus, for evaluating cardiopulmonary function with incremental exercise testing by either treadmill or cycle, we suggest selecting a work rate increment to bring the subject to the limit of his tolerance in about 10 min.
If the phrase "exercise videos" calls to mind Buns of Steel, purple spandex, and leg warmers, you'll be pleasantly surprised. The fitness video industry has come a long way. These days you can find anything from and dance programs to Pilates and yoga on DVD. In fact, there are so many out there that finding the best exercise videos can be a daunting proposition.

Jump up ^ Olsen CM (December 2011). "Natural rewards, neuroplasticity, and non-drug addictions". Neuropharmacology. 61 (7): 1109–1122. doi:10.1016/j.neuropharm.2011.03.010. PMC 3139704. PMID 21459101. Similar to environmental enrichment, studies have found that exercise reduces self-administration and relapse to drugs of abuse (Cosgrove et al., 2002; Zlebnik et al., 2010). There is also some evidence that these preclinical findings translate to human populations, as exercise reduces withdrawal symptoms and relapse in abstinent smokers (Daniel et al., 2006; Prochaska et al., 2008), and one drug recovery program has seen success in participants that train for and compete in a marathon as part of the program (Butler, 2005). ... In humans, the role of dopamine signaling in incentive-sensitization processes has recently been highlighted by the observation of a dopamine dysregulation syndrome in some patients taking dopaminergic drugs. This syndrome is characterized by a medication-induced increase in (or compulsive) engagement in non-drug rewards such as gambling, shopping, or sex (Evans et al., 2006; Aiken, 2007; Lader, 2008).
The purpose of this paper is to investigate the history, origins, and influences of Western MMB training, to raise healthcare stakeholders’ awareness of this type of training and to initiate the consideration of official acceptance of MMB methods as an independent exercise category alongside aerobic training and weightlifting. This would provide decision-makers and individuals with new tools to prescribe optimal exercise combinations for remedial purposes, prevention of pathologies, and obesity as well as general health and performance enhancement. Significantly, these are the major factors that facilitate a regular active lifestyle.
All data are presented as means ± standard deviation (SD) unless stated. Assumptions of statistical tests such as normal distribution and sphericity of data were checked as appropriate. Greenhouse-Geisser correction to the degrees of freedom was applied when violations to sphericity were present. For reliability statistics, assumptions of homoscedasticity and heteroscedasticity were checked as appropriate. Reliability analysis was conducted following the guidelines provided by Atkinson and Nevill [19]. Our sample size of eight subjects is comparable to previous studies using high-intensity OLDE [8, 11, 17].
Two moves is better than one, right? You may want to do this move on a mat or a towel for padding. Start in a high plank position with core tight. Lower onto both forearms at the same time, maintaining a tight core and level hips. Now push back up onto hands at the same time to return to starting position. Finish by drawing right knee into chest, then left knee into chest, doing a mountain climber.
"The saying in CrossFit is that we don't use machines, we are the machines," adds Amy "Pistol" Mandelbaum, owner and head coach of CrossFit Westport. "We use barbells, dumbbells, rowers, kettlebells, and 'rigs' for pull-ups. A CrossFit box is like Tinkertoys for adults. Everything is mobile and can be configured to accommodate different movements. Many exercises are bodyweight-oriented, such as burpees, push-ups, jump rope, pull-ups, running, and more."
Your body clock, that is. Try to work out at the time you have the most energy, suggests Jason Theodosakis, MD, exercise physiologist at the University of Arizona College of Medicine. If you're a morning person, schedule your fitness activities early in the day; if you perk up as the day goes along, plan your activities in the afternoon or evening.
Get your shoulders looking svelte with hand/arm raises. Riggins says here’s how to do them: Raise your hand over head; hand is at a 90-degree angle to the body as if you’re doing shoulder press with no weights. Put your hands up and raise over head; raise up to sky and bring back down. Keep repeating for 30 seconds. We know it sounds too easy, but you’ll feel it start to burn about 20 seconds in!
I have used the standard protocol (10 seconds plus or minus two for both concentric and eccentric contractions) of this method, although sometimes I prefer going a bit faster such as 4/4, 6/6 or 8/8 seconds respectively. It is not easy and even a bit painful to do a single set of each exercise and "inroad" the muscles. Moving from machine to machine between exercises with no rest, one experiences tremendous cardio-respiratory workload (experiences counterpulsation due to very large venous return to the heart) and some feel extreme fatigue when finished. A workout can last as little as 10-12 minutes, based on 5 basic compound exercises (ie: ankle raise, trunk extension, squat, shoulder or chest press, pulldowns), and personally, I found I needed 2 workouts/week in order to achieve the strength gains I desired. Some think only one session per week is needed and I believe this is a personal and time management choice.
This is an extremely high-skill movement, and is one of two Olympic Weightlifting events. HOW TO DO IT: Start with the bar on the ground with your feet hip-width apart. With your hands wide on the bar, keep a big chest as you deadlift the weight off the ground (similar to the beginning of the clean). Pull from the floor with your arms in a locked position. Then, drive your hips and pull the bar as high as possible. As you receive the bar overhead, drop down as quickly as possible and lock your arms into place in a squat position with the bar overhead. MUSCLES USED: Glutes, quads, hamstrings, calves, traps, core, shoulders and back.
Ashley and the team of Strong and Sexy incorporate moves like standing ab pumps, side crunches, and side-to-side leans into fun dance moves that’ll leave you feeling like a professional dancer — even if your abs are burning. As an added bonus, the dancer on the right side of the screen shows you how to perform lower-intensity versions of each dance move.
^ Jump up to: a b c d Basso JC, Suzuki WA (March 2017). "The Effects of Acute Exercise on Mood, Cognition, Neurophysiology, and Neurochemical Pathways: A Review". Brain Plasticity. 2 (2): 127–152. doi:10.3233/BPL-160040. Lay summary – Can A Single Exercise Session Benefit Your Brain? (12 June 2017). A large collection of research in humans has shown that a single bout of exercise alters behavior at the level of affective state and cognitive functioning in several key ways. In terms of affective state, acute exercise decreases negative affect, increases positive affect, and decreases the psychological and physiological response to acute stress [28]. These effects have been reported to persist for up to 24 hours after exercise cessation [28, 29, 53]. In terms of cognitive functioning, acute exercise primarily enhances executive functions dependent on the prefrontal cortex including attention, working memory, problem solving, cognitive flexibility, verbal fluency, decision making, and inhibitory control [9]. These positive changes have been demonstrated to occur with very low to very high exercise intensities [9], with effects lasting for up to two hours after the end of the exercise bout (Fig. 1A) [27]. Moreover, many of these neuropsychological assessments measure several aspects of behavior including both accuracy of performance and speed of processing. McMorris and Hale performed a meta-analysis examining the effects of acute exercise on both accuracy and speed of processing, revealing that speed significantly improved post-exercise, with minimal or no effect on accuracy [17]. These authors concluded that increasing task difficulty or complexity may help to augment the effect of acute exercise on accuracy. ... However, in a comprehensive meta-analysis, Chang and colleagues found that exercise intensities ranging from very light (<50% MHR) to very hard (>93% MHR) have all been reported to improve cognitive functioning [9].
After trying many different workout "schemes" with limited success, I bought this book and began doing Super Slow workouts. I'm now working out 6 times a month, spending less than 30 minutes in the gym for each workout, and I'm stronger than I've ever been. I've never experienced progress like this before. At 45 years old, my leg press has gone from 400 to 820 lbs. in a couple of months. The workouts aren't easy, but they're over quickly, and I'm able to spend more time with my family without feeling like I'm compromisng my health and fitness.
For today's workout, you'll go through the following eight yoga poses, holding each for 3 to 5 breaths. Do the workout anytime you like—it will refresh you in the morning and help you unwind before bed. Take your time when performing each exercise and focus on your breath: Breath in and out through the nose, taking the air in through the back of your throat. Do each pose at least once, twice or more if you have time.

I must confess: the title of this section is misleading, because while most of us associate the first home workouts with fitness icons Jane Fonda and Richard Simmons, they were not the first ones to bring workouts inside our homes. In fact, before there were VHS tapes, before there were even televised workouts, there were the audio-only vinyl record workouts, nicknamed vinylcise.
Barre workouts require minimal equipment. You’ll need a free-standing or wall mounted bar and a mat. Sometimes a soft exercise ball may be used during leg workouts. If you are taking classes in a studio, the required equipment will most likely be provided for you. If you are working out at home, bars can be purchased for home use. You may prefer to be barefoot or purchase socks with grips on the bottom. As with all other workouts, having a water bottle and towel nearby is helpful.
11. De Vries N. M., van Ravensberg C. D., Hobbelen J. S. M., Olde Rikkert M. G. M., Staal J. B., Nijhuis-van der Sanden M. W. G. Effects of physical exercise therapy on mobility, physical functioning, physical activity and quality of life in community-dwelling older adults with impaired mobility, physical disability and/or multi-morbidity: a meta-analysis. Ageing Research Reviews. 2012;11(1):136–149. doi: 10.1016/j.arr.2011.11.002. [PubMed] [Cross Ref]