Developing research has demonstrated that many of the benefits of exercise are mediated through the role of skeletal muscle as an endocrine organ. That is, contracting muscles release multiple substances known as myokines which promote the growth of new tissue, tissue repair, and multiple anti-inflammatory functions, which in turn reduce the risk of developing various inflammatory diseases.[114] Exercise reduces levels of cortisol, which causes many health problems, both physical and mental.[115] Endurance exercise before meals lowers blood glucose more than the same exercise after meals.[116] There is evidence that vigorous exercise (90–95% of VO2 max) induces a greater degree of physiological cardiac hypertrophy than moderate exercise (40 to 70% of VO2 max), but it is unknown whether this has any effects on overall morbidity and/or mortality.[117] Both aerobic and anaerobic exercise work to increase the mechanical efficiency of the heart by increasing cardiac volume (aerobic exercise), or myocardial thickness (strength training). Ventricular hypertrophy, the thickening of the ventricular walls, is generally beneficial and healthy if it occurs in response to exercise.
The link between physical health and exercise (or lack of it) was further established in 1949 and reported in 1953 by a team led by Jerry Morris.[147][148] Dr. Morris noted that men of similar social class and occupation (bus conductors versus bus drivers) had markedly different rates of heart attacks, depending on the level of exercise they got: bus drivers had a sedentary occupation and a higher incidence of heart disease, while bus conductors were forced to move continually and had a lower incidence of heart disease.[148]
Rep schemes remain in the hypertrophy range this week, but overall volume increases by adding more sets to individual exercises: up to five sets per move for larger bodyparts, and even 10 sets of calf raises on Thursday. This bump in volume will ensure that your muscles are overloaded sufficiently to continue the growth they’ve already begun experiencing in the first three weeks. Completion of this four-week program now entitles you to go to the next stage.
* If you're looking to control your weight, exercise is the least efficient way to do it. You'd have to run for hours to keep the cookies you ate from adding to your waistline. It's far more effective to not eat the cookies. Making fruits and vegetables a larger part of your diet will help crowd out the foods that don't offer much in the way of nutrition, and which add pounds that shouldn't be there. Also, as you build lean muscle tissue, your body will lessen its fatty tissue, and your shape will change. If you're overweight, you're not trying to lose weight, you're trying to lose fat. If your goal is to look and feel great, strength building exercise will accomplish this while making you fit in the process. Doing only aerobics will not.
Recruitment criteria were one or both of sedentariness and dysmetabolism. Thus, we selected subjects who were not physically active or involved in any exercise program; that is, they had a sedentary lifestyle. Moreover, before entering the study, they were carefully screened for metabolic problems which attested a dysmetabolic status, as increased levels of plasma glucose, free fatty acids, triglyceride, and urate in fasting state. Both criteria were verified by means of family doctor databases of subjects.