In her hilarious, naked, and explicitly honest anecdote, she described her aversion to most fitness regimens ("I can't run because I piss myself . . . and fart at the same time"), her DVD workout — "Charlotte's 3-Minute Belly Blitz" — and her complete surprise at the intensity of the routine ("THAT'S the f*cking WARMUP?"). To be honest, most of us have been there, so this is pretty damn relatable.
The benefits of exercise have been known since antiquity. Dating back to 65 BCE, it was Marcus Cicero, Roman politician and lawyer, who stated: "It is exercise alone that supports the spirits, and keeps the mind in vigor." Exercise was also seen to be valued later in history during the Early Middle Ages as a means of survival by the Germanic peoples of Northern Europe.
Two incremental graded exercise tests until exhaustion were performed, with 4 h of rest in between. One hour before each test, the athletes received a standardised meal (2315 kJ, 73% carbohydrate, 19% protein, 8% fat). Athletes arrived in the laboratory at 07:00 after an overnight fast. The first blood sample was collected as they arrived. Immediately after the first exercise test, the second blood sample was drawn. The third and fourth blood samples were drawn before and immediately after the second test. A schematic overview of the protocol can be found in fig 1. Because it is known that venepuncture increases blood prolactin, going back to baseline within 30 min, blood was drawn before and after each test (four punctures) creating the same “stress” in each situation. The study protocol was approved by the university ethical committee.
It is well known that exercise in the older population may prevent several diseases [1–4]. Reduced physical activity impairs the quality of life in elderly people with Alzheimer's Disease , Parkinson's Disease , and Depressive Disorders . Moreover, musculoskeletal, cardiopulmonary, and cerebrovascular decline are associated with poor physical fitness because of the cumulative effects of illness, multiple drug intake, fatigue, and bed rest [7, 8]. The effects of physical activity and exercise programs on fitness and health-related quality of life (HRQOL) in elderly adults have been widely studied by several authors [9–11]. De Vries et al.  conducted a meta-analysis focusing on elderly patients with mobility problems and/or multimorbidity. Eighteen articles describing a wide variety of actions were analyzed. Most used a multicomponent training program focusing on the combination of strength, balance, and endurance training. In 9 of the 18 studies included, interventions were supervised by a physical therapist. Intensity of the intervention was not reported and the duration of the intervention varied from 5 weeks to 18 months. This meta-analysis concluded that, considering quality of life, the exercise versus no-exercise studies found no significant effects. High-intensity exercise appears to be somewhat more effective in improving physical functioning than low-intensity exercise. These positive effects are of great value in the patient population but the most effective type of intervention remains unclear. Brovold et al.  recently examined the effects of high-intensity training versus home-based exercise programs using the Norwegian Ullevaal Model  on a group of over-65-year-olds after discharge from hospital. These authors based their study on the Swedish Friskis-Svettis model  which was designed by Johan Holmsater for patients with coronaropathy to promote their return to work and everyday activities and improve their prognoses. This model includes three intervals of high intensity and two intervals of moderate intensity, each one lasting for 5 to 10 minutes. Included in each is coordination. Exercises consist of simple aerobic dance movements and involve the use of both upper and lower extremities to challenge postural control . Exercise intensity was adjusted using the Borg Rating of Perceived Exertion (RPE) Scale. Moderate intensity was set between 11 and 13, and high intensity was set between 15 and 17 on the Borg Scale.